Umbria, in Central Italy, is the only Italian region that has neither a coastline nor a shared border with another country, although Lazio, Tuscany and Le Marche surround it. Containing only two provinces, Perugia and Terni, it is crossed by the great River Tiber, and is home to huge Lake Trasimeno. The beautiful hilltop medieval regional capital is Perugia, which has for centuries been an important hub of knowledge and learning - one of Italy’s oldest universities is here, dating back to 1308. It is Assisi, however, that is probably the most visited town in Umbria, being the birthplace of two significant saints in Italian history: Saint Francis and Saint Clare, a fact that makes the city one of the main destinations for pilgrims.