Stir together the ketchup, vegetable juice, horseradish, lime juice, hot sauce, and garlic powder until well blended. Taste and add more horseradish or hot sauce if you would like it spicier.
Add the onion, cilantro, and shrimp and mix well. Gently stir in the avocado.
Cover and refrigerate 2 to 3 hours.
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