Rinse tilapia fillets and pat dry with paper towels.
Mix flour, garlic powder, pepper, and salt in a shallow dish. Dip fillets in flour mixture and coat both sides.
Heat butter in skillet over medium heat until hot. Add floured fillets to skillet and pan fry for 3 to 4 minutes on each side or until golden.
Place fillets on a platter and spoon the mango and avocado salsa over fish before serving.
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